Sunday, June 30, 2013

Despite loss of its combat troops, Fort Knox's iconic status and role in pop culture endure

FORT KNOX, Ky. ? Few military posts have a place in pop culture as rock solid as Kentucky's Fort Knox, thanks to its mysterious gold vault.

The name of the historic base is practically synonymous with impenetrability. In addition to housing the Treasury Department's U.S. Bullion Depository and its stacks of gold, the Army's tank training school was started at Fort Knox. And the sprawling central Kentucky Army post has been the setting for blockbuster Hollywood films.

But Knox's days as a war-fighting post may be over with the Pentagon's decision last week to strip its only combat brigade, which follows the loss of its famed armor school and thousands of tank personnel just a few years ago. The base will remain the site of the gold vault, but otherwise it could be destined to function less as a tip-of-the-spear military facility and more as a home to office and support workers.

Many of those workers file into a nearly million-square-foot structure on post that was completed a few years ago, but the massive building doesn't seem destined to unseat the vault as the symbol of Fort Knox.

"It is kind of an icon. Most people when they see the outline of the depository, they know what it is," said Harry Berry, a retired Army lieutenant colonel who is now judge-executive in Hardin County. "When you think about Fort Knox, if you don't have a military background, you instantly think about gold or 'Goldfinger,'" the 1960s James Bond film.

The Pentagon announced last week that it was eliminating Knox's 3rd Brigade Combat Team, 1st Infantry Division as part of a major restructuring that will reduce the Army's active duty combat brigades to 33 from 45. The cuts will reduce the size of the Army from about 570,000 in the midst of the Iraq war down to 490,000, which includes personnel in units that support the brigades.

For some posts, that means the loss of a few hundred soldiers, but in Knox's case it's a cut of more than 40 percent to its active duty force and nearly a total elimination of its fighting personnel. Kentucky Gov. Steve Beshear puts the figure at about 10,000 lost troops and their families leaving Knox and the surrounding area.

Gen. Ray Odierno, Army chief of staff, said the military was not moving toward closing Knox: He pointed out that the Army's recruiting and human resource commands have relocated there since a major Army realignment almost a decade ago.

Baldy Carder, who owns a tattoo parlor in nearby Radcliff, said he's not worried about the post closing ? "because of the gold reserve." But he said his business could take a hit since about half his customers come from the post.

"When you're talking about 10,000 people leaving, that's quite a chunk of change that we're going to be losing," he said.

Fort Knox's own estimates project that its annual economic impact will shrink from about $2.8 billion a year to $2.62 billion upon the brigade's departure, said Ryan Brus with the post's public affairs office. That's a decrease of more than 6 percent.

Source: http://www.startribune.com/politics/national/213746731.html

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Kentucky Announces Online Gaming Settlement | LEX18.com ...

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    Source: http://www.lex18.com/news/kentucky-announces-online-gaming-settlement-340977/

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    Saturday, June 29, 2013

    News Corp splits after Friday close

    NEW YORK (AP) ? News Corp. formally split in two after the market closed on Friday, with existing shareholders getting one share in the new publishing entity for every four shares they hold in the media company.

    Since Wednesday last week, preliminary shares of both sides of the company have been trading as if the split already occurred. Any buyers of preliminary shares will receive them next Friday.

    Preliminary publishing shares closed Friday at $15.25.

    The recent trading valued the publishing division, to be named News Corp., at around $8.8 billion. That's about 12 percent of the entire company's value. It had a market capitalization of about $75.5 billion before the split.

    The movie and TV division is being renamed Twenty-First Century Fox Inc. Its preliminary stock closed at $28.99 on Friday.

    Shares of both entities will begin trading normally on Monday, with new News Corp. shares trading under the tickers "NWSA" for non-voting Class A shares and "NWS" for voting Class B shares. Twenty-First Century Fox shares will trade under the tickers "FOXA" for non-voting Class A shares and "FOX" for voting Class B shares.

    Rupert Murdoch, who will be chairman of both companies and CEO of Twenty-First Century Fox, will retain his grip on both companies by controlling nearly 40 percent of the voting stock in each.

    The split completes a process that the company announced a year ago, and responds to investor concerns that the newspaper and book publishing divisions were dragging on the faster growing pay TV business.

    By separating, the publishing division can devote resources toward engineering a turnaround, while the Fox side focuses on launching a national sports network to be called Fox Sports 1 that will compete with pay TV leader ESPN.

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-06-28-News%20Corp-Split/id-e48ec5f6fcc3493f8a5b05f25883beea

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    Obama tells leaders to follow Mandela's example

    U.S. President Barack Obama and South African President Jacob Zuma, not pictured, address a press conference following their meeting at Union Building in Pretoria, South Africa, Saturday June 29, 2013.(AP Photo/Jerome Delay)

    U.S. President Barack Obama and South African President Jacob Zuma, not pictured, address a press conference following their meeting at Union Building in Pretoria, South Africa, Saturday June 29, 2013.(AP Photo/Jerome Delay)

    U.S. President Barack Obama gestures during a news conference with South African President Jacob Zuma, not pictured, at the Union Building on Saturday, June 29, 2013, in Pretoria, South Africa. The president is in South Africa, embarking on the second leg of his three-country African journey. The visit comes at a poignant time, with former South African president and anti-apartheid hero Nelson Mandela ailing in a Johannesburg hospital. (AP Photo/Evan Vucci)

    El presidente Barack Obama, izquierda, habla con su contraparte de Sud?frica Jacob Zuma el s?bado, 29 de junio del 2013 en Pretoria, Sud?frica. (Foto AP/Evan Vucci)

    U.S. President Barack Obama and South African President Jacob Zuma address a press conference following their meeting at Union Building in Pretoria, South Africa, Saturday June 29, 2013.(AP Photo/Jerome Delay)

    U.S. President Barack Obama flanked by First Lady Michelle Obama, left, waves with South African President Jacob Zuma, second right, and his wife Tobeka Madiba Zuma, right, on the steps of Union Building in Pretoria, South Africa, Saturday June 29, 2013. (AP Photo/Jerome Delay)

    (AP) ? President Barack Obama encouraged leaders in Africa and around the world Saturday to follow former South African President Nelson Mandela's example of country before self, as the U.S. president prepared to pay personal respects to relatives who have been gathered around the critically ill anti-apartheid icon.

    "We as leaders occupy these spaces temporarily and we don't get so deluded that we think the fate of our country doesn't depend on how long we stay in office," Obama said.

    Obama spoke at a news conference with South African President Jacob Zuma in the midst of a weeklong tour of the continent that also included stops in Senegal and Tanzania. But many other African nations are embroiled in religious, sectarian and other conflicts.

    Obama decided to avoid stopping in his father's home nation of Kenya because of international disputes there. The International Criminal Court is prosecuting Kenyan President Uhuru Kenyatta for crimes against humanity, including murder, deportation, rape, persecution and inhumane acts allegedly committed by his supporters in the violent aftermath of Kenya's 2007 elections.

    "The timing was not right for me as the president of the United States to be visiting Kenya when those issues are still being worked on, and hopefully at some point resolved," Obama said. He noted he's visited Kenya several times previously and expects he will as well in the future.

    Obama and Zuma appeared at the Union Buildings that house government offices and the site of Mandela's 1994 inauguration as the country's first black president after 27 years behind bars for his activism.

    The 94-year-old Mandela has been in a nearby hospital for three weeks after being admitted with a lung infection. Zuma told reporters that Mandela is in critical but stable condition and the whole nation is praying that he will improve.

    Obama and his wife visited with some of Mandela's relatives Saturday at the Nelson Mandela Centre of Memory, part of the former president's foundation. The White House didn't say which relatives were meeting with Obama. In accordance with the family's wishes, Obama doesn't plan to visit with Mandela.

    Obama revered Mandela as "one of the greatest people in history," referred to him by his clan name as he praised South Africa's historic integration from white racist rule as a shining beacon for the world.

    "The struggle here against apartheid for freedom, Madiba's moral courage, this country's historic transition to a free and democratic nation has been a personal inspiration to me, it has been an inspiration to the world," Obama said.

    "The outpouring of love that we've seen in recent days shows that the triumph of Nelson Mandela and this nation speaks to something very deep in the human spirit, the yearning for justice and dignity that transcends boundaries of race and class and faith and country," Obama said. "That's what Nelson Mandela represents, that's what South African at its best represents to the world, and that's what brings me back here."

    Zuma told Obama he and Mandela are "bound by history as the first black presidents of your respective countries."

    "Thus, you both carry the dreams of millions of people in Africa and in the diaspora who were previously oppressed," Zuma said, reading from a prepared statement.

    On other topics, Obama declined to commit to supporting South Africa's bid for a permanent seat on the United Nations Security Council. He said the U.N.'s structure needs to be updated and it would be "odd" for an expanded Security Council not to have African representation.

    "How we do that and what fashion is complicated, it's difficult and it involves all kinds of politics," Obama said.

    "Everybody wants a seat at the table, but when it comes time to step up and show responsibility, sometimes people want to be free riders," Obama said, adding he wasn't referring to South Africa specifically.

    Zuma responded that he wishes the process of change at the U.N. would speed up.

    Obama also said he wants to boost trade with Africa and plans to renegotiate an African trade pact to improve it for American businesses. He said he welcomes competition from other nations who have been aggressive in pursuing commercial opportunities in Africa, including China.

    "I don't feel threatened by it. I think it's a good thing," he said. He added: "Our only advice is make sure it's a good deal for Africa." He said that includes making sure foreign investment employs Africans and doesn't tolerate corruption or take its natural resources without compensation for Africans.

    Obama also is paying tribute to South Africa's fight against apartheid by visiting the Soweto area Saturday afternoon for a town hall with students at the University of Johannesburg. At least 176 young people were killed in Soweto township 27 years ago this month during a youth protest against the apartheid regime's ban against teaching local Bantu languages. The Soweto Uprising catalyzed international support against apartheid, and June is now recognized as Youth Month in South Africa.

    The university plans to bestow an honorary law degree on the U.S. president.

    Protesters under police watch demonstrated outside the university against Obama's record on surveillance and foreign policy. Demonstrators from a range of trade unions and civil society groups chanted, "Away with intelligence, away," holding posters depicting Obama with an Adolf Hitler moustache.

    "People died in Libya. People are still dying in Syria," said 54-year-old Ramasimong Tsokolibane. "In Egypt, in Afghanistan in Pakistan drones are still killing people. So that's why we are calling him a Hitler. He's a killer."

    Obama has been trying to inspire the continent's youth to become civically active and part of a new democratically minded generation. Obama hosted young leaders from more than 40 African countries at the White House in 2010 and challenged them to bring change to their countries by standing up for freedom, openness and peaceful disagreement.

    Obama wraps up his South Africa stay Sunday, when he plans to give a sweeping speech on U.S.-Africa policy at the University of Cape Town and take his family to Robben Island to tour the prison where Mandela spent 18 of his 27 years behind bars.

    Obama has visited the island before, but said it's a particular privilege to bring his daughters back to learn its lessons.

    ___

    Associated Press Television News reporter Bram Janssen contributed to this report.

    Follow Nedra Pickler on Twitter at https://twitter.com/nedrapickler and Julie Pace at https://twitter.com/jpacedc

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-06-29-Obama/id-465df6f9c1a042fd9fdf0fb2c592da84

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    Obama recasts chase for Snowden as unexceptional

    WASHINGTON (AP) ? The last thing President Barack Obama wants to do is turn Edward Snowden into a grand enemy of the state or a Daniel Ellsberg-type hero who speaks truth to power.

    In the shifting narrative of the Obama administration, the man whose leaks of top-secret material about government surveillance programs have tied the national security apparatus in knots and brought charges under the Espionage Act has now been demoted to a common fugitive unworthy of international intrigue or extraordinary pursuit by the U.S. government.

    A "29-year-old hacker," in the words of Obama; fodder for a made-for-TV movie, perhaps, but not much more.

    "This is not exceptional from a legal perspective," the president said Thursday of Snowden's efforts to avoid capture by hopscotching from Hawaii to Hong Kong to Russia.

    "I'm not going to have one case of a suspect who we're trying to extradite suddenly being elevated to the point where I've got to start doing wheeling and dealing and trading on a whole host of other issues simply to get a guy extradited," the president told reporters in Senegal.

    It was the second time in a week that the administration had toned down its rhetoric as Snowden remained out of reach and first China and then Russia refused to send him back.

    Just Monday, Secretary of State John Kerry was talking tough against China and calling Snowden a traitor whose actions are "despicable and beyond description." By Tuesday, Kerry was calling for "calm and reasonableness" on the matter, and adding, "We're not looking for a confrontation. We are not ordering anybody."

    There are plenty of reasons for Obama to pull back, beyond his professed desire to avoid international horse-trading for the leaker.

    The president, in his own words, has "a whole lot of business to do with China and Russia." Why increase tensions in an already uneasy relationship when Obama is looking for Russia's cooperation in finding a path to peace in Syria, for example?

    In addition, less-heated dialogue could make it easier to broker Snowden's return because, despite the latest shrugs, U.S. officials very much want him.

    "There's a lot of signaling going on," said Steve Aftergood, director of the Project on Government Secrecy for the Federation of American Scientists. "If the White House were issuing ultimatums, then Russia might feel obliged not to cooperate. But if it's merely one request among many others, that might make it easier to advance to a resolution."

    The president also may have a U.S. audience in mind for his comments.

    Obama's Democratic base includes plenty of defenders of civil liberties who are sympathetic to Snowden's professed goal of making government more transparent.

    Benjamin Pauker, managing editor of Foreign Policy magazine, said the president was loath to elevate Snowden to a state enemy or "an Ellsberg-type truth-teller," referring to the 1971 leaker of the Pentagon Papers, which showed the U.S. government had misled the public about the war in Vietnam.

    Ellsberg himself recently called Snowden's revelations the most significant disclosures in the nation's history.

    The administration, though, would rather marginalize Snowden, a former National Security Agency systems analyst who is thought to have custody of more classified documents.

    "Calling him a hacker, as opposed to a government contractor or an NSA employee, brings him down a notch to someone who's an irritant, as opposed to someone who has access to integral intelligence files," Pauker said. "To externalize him and brand him with a black-hat hacker tag distances him from the government."

    The disdainful talk isn't just coming from the White House.

    Rep. Mike Rogers, R-Mich., the chairman of the House Intelligence Committee, called Snowden "a high school dropout who had a whole series of both academic troubles and employment troubles" after a recent closed hearing on the leaks. The committee's top Democrat, C.A. "Dutch" Ruppersberger from Maryland, called Snowden "a legend in his own mind" for claiming to be able to use NSA systems to access any email or phone call anywhere ? something the NSA's director has said can't be done.

    There may also be face-saving benefits for Obama in cutting down Snowden, who turned 30 last week. An unsuccessful full-court press for Snowden's return would only show the limitations of Obama's international influence.

    It's not the first time a president has tried to reset expectations by first elevating and then playing down the importance of an international fugitive who eluded capture, at least for a time.

    President George W. Bush went from putting out a "dead-or-alive" ultimatum for 9-11 terror mastermind Osama bin Laden to dismissing him as "a person who's now been marginalized."

    "I just don't spend that much time on him," Bush said in March 2002.

    Candidate Barack Obama pledged during the 2008 presidential campaign: "We will kill bin Laden, we will crush al-Qaida. That has to be our biggest national security priority."

    By January 2009, just days before his inauguration, Obama was saying: "My preference, obviously would be to capture or kill him. But if we have so tightened the noose that he's in a cave somewhere and can't even communicate with his operatives, then we would meet our goal of protecting America."

    As it turned out, he got him.

    ___

    AP Intelligence Writer Kimberly Dozier contributed to this report.

    ___

    Follow Nancy Benac on Twitter: http://www.twitter.com/nbenac

    Source: http://news.yahoo.com/obama-recasts-chase-snowden-unexceptional-073112725.html

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    Friday, June 28, 2013

    Polymer coatings a key step toward oral delivery of protein-based drugs

    June 27, 2013 ? For protein-based drugs such as insulin to be taken orally rather than injected, bioengineers need to find a way to shuttle them safely through the stomach to the small intestine where they can be absorbed and distributed by the bloodstream. Progress has been slow, but in a new study, researchers report an important technological advance: They show that a "bioadhesive" coating significantly increased the intestinal uptake of polymer nanoparticles in rats and that the nanoparticles were delivered to tissues around the body in a way that could potentially be controlled.

    "The results of these studies provide strong support for the use of bioadhesive polymers to enhance nano- and microparticle uptake from the small intestine for oral drug delivery," wrote the researchers in the Journal of Controlled Release, led by corresponding author Edith Mathiowitz, professor of medical science at Brown University.

    Mathiowitz, who teaches in Brown's Department of Molecular Pharmacology, Physiology, and Biotechnology, has been working for more than a decade to develop bioadhesive coatings that can get nanoparticles to stick to the mucosal lining of the intestine so that they will be taken up into its epithelial cells and transferred into the bloodstream. The idea is that protein-based medicines would be carried in the nanoparticles.

    In the new study, which appeared online June 21, Mathiowitz put one of her most promising coatings, a chemical called PBMAD, to the test both on the lab bench and in animal models. Mathiowitz and her colleagues have applied for a patent related to the work, which would be assigned to Brown University.

    In prior experiments, Mathiowitz and her group have shown not only that PBMAD has bioadhesive properties, but also that it withstands the acidic environment of the stomach and then dissolves in the higher pH of the small intestine.

    Adhere, absorb, arrive

    The newly published results focused on the question of how many particles, whether coated with PBMAD or not, would be taken up by the intestine and distributed to tissues. For easier tracking throughout the body, Mathiowitz's team purposely used experimental and control particles made of materials that the body would not break down. Because they were "non-erodible" the particles did not carry any medicine.

    The researchers used particles about 500 nanometers in diameter made of two different materials: polystyrene, which adheres pretty well to the intestine's mucosal lining, and another plastic called PMMA, that does not. They coated some of the PMMA particles in PBMAD, to see if the bioadhesive coating could get PMMA particles to stick more reliably to the intestine and then get absorbed.

    First the team, including authors Joshua Reineke of Wayne State University and Daniel Cho of Brown, performed basic benchtop tests to see how well each kind of particles adhered. The PBMAD-coated particles proved to have the strongest stickiness to intestinal tissue, binding more than twice as strongly as the uncoated PMMA particles and about 1.5 times as strongly as the polystyrene particles.

    The main experiment, however, involved injecting doses of the different particles into the intestines of rats to see whether they would be absorbed and where those that were taken up could be found five hours later. Some rats got a dose of the polystyrene particles, some got the uncoated PMMA and some got the PBMAD-coated PMMA particles.

    Measurements showed that the rats absorbed 66.9 percent of the PBMAD-coated particles, 45.8 percent of the polystyrene particles and only 1.9 percent of the uncoated PMMA partcles.

    Meanwhile, the different particles had very different distribution profiles around the body. More than 80 percent of the polystyrene particles that were absorbed went to the liver and another 10 percent went to the kidneys. The PMMA particles, coated or not, found their way to a much wider variety of tissues, although in different distributions. For example, the PBMAD-coated particles were much more likely to reach the heart, while the uncoated ones were much more likely to reach the brain.

    Pharmaceutical potential

    The apparent fact that the differing surface properties of the similarly sized particles had such distinct distributions in the rats' tissues after the same five-hour period suggests that scientists could learn to tune particles to reach specific parts of the body, essentially targeting doses of medicines taken orally, Mathiowitz said.

    "The distribution in the body can be somehow controlled with the type of polymer that you use," she said.

    For now, she and her group have been working hard to determine the biophysics of how the PBMAD-coated particles are taken up by the intestines. More work also needs to be done, for instance to demonstrate actual delivery of protein-based medicines in sufficient quantity to tissues where they are needed.

    But Mathiowitz said the new results give her considerable confidence.

    "What this means now is that if I coat bioerodible nanoparticles correctly, I can enhance their uptake," she said. "Bioerodible nanoparticles are what we would ultimately like to use to deliver proteins. The question we address in this paper is how much can we deliver. The numbers we saw make the goal more feasible."

    Another frontier for the delivery of nanoparticles is devising a safe method to make nanoparticles, Mathiowitz said, but, "we have already developed safe and reproducible methods to encapsulate proteins in tiny nanoparticles without compromising their biological activity."

    In addition to Reineke, Cho, and Mathiowitz, other authors on the paper are Yu-Ting Liu Dingle, Stacia Furtado, Bryan Laulicht, Danya Lavin, and Peter M. Cheifetz, all of Brown University during the research.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/XPzxGGf6RI8/130627125317.htm

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